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KMID : 0370020030170000005
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Chung-Ang Journal of Pharmacal Sciences
2003 Volume.17 No. 0 p.5 ~ p.21
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The Antioxidative and The Anti-diabetic Effects of Phellinus linteus as Ethno-Medicinal Preparation
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Abstract
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This studies were attempted to evaluate the antioxidant and the antidiabetive activities of Phellinus linteus and its preparation.
The DPPH was revealed that Phellinus linteus and Allium cepae bulbus mixture had significantly antioxidant activity. TEARS assay showed that Phellinus linteus and Houttuyniae herbal mixture and Phellinus linteus and Ginseng radix rubra ´mixture had significantly anti-lipid peroxidative efficacy when compared to that of contrast drug, ascorbic acid.
The effect of Phellinus linteus and its preparation on Diabetic animal model were investigated in streptozotocin-induced diabetic SD rats. The blood glucose was dose-dependently decreased when each 50, 100, 200 ㎏/㎎ fraction of Phellinus linteus and ginseng radix rubra mixture was administrated significantly. The serum total cholesterol was showed inhibitive activity when each 50, 100, 200 ㎏/㎎ fraction of Phellinus linteus and ginseng radix rubra ´mixture was administrated.
Especially 200 ㎎/㎏ fraction was dose-dependently decreased. The serum triglyceride hyperglycemic rats was dose-dependently decreased when each 50, 100, 200 ㎏/㎎ fraction of Phellinus linteus and ginseng radix rubra mixture was administrated. But when Phellinus linteus and Allium cepae bulbus mixture and Phellinus linteus and Houttuyniae herbal mixture increased dose, the serum total cholesterol and the serum triglyceride hyperglycemic rats were increased too.
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